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. 2021 Feb;9(3):234. doi: 10.21037/atm-19-4738

Figure 6.

Figure 6

LY294002 and Bay11-7082 attenuated cell adhesion and ICAM-1/VCAM-1 protein provoked by hyperglycemia. GDM-HUVECs were pretreated with LY294002 (LY, 50 µM, 24 h) and Bay11-7082 (BAY, 1 µM, 24 h). (A) P-Akt, p-IκBα, and p-p65 protein expression. Data are presented as mean ± SEM; n=5, *, P<0.05 vs. N; #, P<0.05 vs. GDM. Histograms were made according to the ratio of phosphorylated protein/total protein. (B) ICAM-1, VCAM-1 protein expression. (C) Cell adhesion. Data are presented as mean ± SEM; n=5, *, P<0.05 vs. N; #, P<0.05 vs. GDM. Scale bar in C: ×200 and ×400. HUVECs, human umbilical vein endothelial cells; GDM, gestational diabetes mellitus; ICAM-1, intercellular cell adhesion molecule-1; VCAM-1, vascular cell adhesion protein 1.