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The mechanism of hyperglycemia-induced cell adhesion. The effect of hyperglycemia-induced Cx43 on cell adhesion is related to the modulation of PI3K/AKT/NF-κB signaling pathway activity and the regulation of its downstream ICAM-1 and VCAM-1 protein expression. Cx43, Connexin43; ICAM-1, intercellular cell adhesion molecule-1; VCAM-1, vascular cell adhesion protein 1.
