Table 2. Serum IL-1 family cytokines levels of primary ITP, SLE-TP, and SLE-NTP patients (pg/mL).
| Variables | ITP (n=17) | SLE-TP (n=17) | SLE-NTP (n=19) | Health controls (n=10) |
|---|---|---|---|---|
| IL-1F2 (IL-1β) | 3.24 (1.5–5.04)*# | 17.35 (4.87–33.08) | 19.78 (12.9–39.55) | 21.96 (18.06–30.43) |
| IL-1F3 (IL-1Ra) | 57.61 (38.23–104.74)# | 21.3 (10.03–75.62) | 24.12 (12.58–48.48) | 31.11 (19.84–55.1) |
| IL-1F4 (IL-18) | 184.66 (113.92–334.54)*# | 6,935.64 (281.53–9,297.78) | 8,847.64 (5,663.6–10,464.8) | 7,497.2 (5,967.43–8,144.15) |
| IL-1F5 (IL-36Ra) | 1,103.8 (406.95–4,497.75) | 1,150.49 (131.35–3,301.73) | 4,073.22 (1,884.32–4,863.08)* | 246.05 (77.23–997.78) |
| IL-1F6 (IL-36α) | 32.2 (20–54.4)*# | 366.85 (91.88–939.57) | 499.7 (396.6–1,055.81) | 790.7 (366.63–1,519.55) |
| IL-1F7 (IL-37) | 23.49 (20–28.35)*# | 30.29 (22.06–38.67)* | 44.67 (30.36–91.39)# | 83.96 (27.1–238.27) |
| IL-1F8 (IL-36β) | 1.04 (0.5–1.28)*# | 10.97 (2.56–35.15) | 17.26 (4.62–30.25) | 19.79 (16.58–38.93) |
| IL-1F9 (IL-36γ) | 20 (20–33.25)*# | 1,151.51 (34.32–1,422.48) | 1,309.63 (742.73–2,276.75) | 2,074.9 (1,136.68–2,649.83) |
| IL-1F10 (IL-38) | 36.84 (29.89–47.16)* | 36.9 (29.1–68.13)* | 47.21 (35.73–92.29)* | 569.97 (366.32–691.12) |
| IL-1F11 (IL-33) | 8.75 (7–18.66)*# | 32.63 (18.01–51.13)* | 45.59 (27.7–68.05) | 46.99 (38.16–115.9) |
Data are presented as median (interquartile range). *, P<0.05 compared to health control; #, P<0.05 compared to SLE-TP. ITP, immune thrombocytopenia; SLE-TP, systemic lupus erythematosus-associated thrombocytopenia; SLE-NTP, SLE without thrombocytopenia.