2. In-hospital clinical outcomes in the entire population.

	Non-thrombocytopenia (n = 461, DPC ≤ 50%)	Thrombocytopenia (n = 249, DPC > 50%)	P-value	Unadjusted OR	95% CI	Adjusted OR	95% CI	P-value
Data are presented as n (%). *Presented as median (interquartile range). CI: confidence interval; DPC: drop in platelet count; ICU: intensive care unit; LOS: length of stay; OR: odds ratio.
Clinical outcomes
In-hospital mortality	68 (14.8%)	66 (26.5%)	< 0.001	2.08	1.42−3.05	0.91	0.49−1.70	0.913
In-ICU mortality	55 (11.9%)	55 (22.1%)	< 0.001	2.08	1.38−3.13	0.98	0.50−1.89	0.940
Major bleeding	79 (17.1%)	89 (35.7%)	< 0.001	2.69	1.89−3.84	2.76	1.80−4.23	< 0.001
Hospital LOS, day	8.09 (4.86−15.42)*	10.81 (6.64−19.41)*	< 0.001	−	−	−	−	−
ICU LOS, day	2.92 (1.79−5.19)*	5.13 (2.92−9.69)*	< 0.001	−	−	−	−	−
Other clinical complications
Transfusion	28 (6.1%)	39 (15.7%)	< 0.001	2.87	1.72−4.80	2.93	1.51−5.68	0.002
Transfusion of red blood cell	27 (5.9%)	38 (15.3%)	< 0.001	2.90	1.72−4.87	2.89	1.47−5.69	0.002
Transfusion of platelet	8 (1.7%)	9 (3.6%)	0.118	2.12	0.81−5.57	−	−	−
Tromboembolic events	4 (0.9%)	6 (2.4%)	0.183	2.82	0.79−10.09	−	−	−
Post-procedural renal insufficiency	70 (15.2%)	87 (34.9%)	< 0.001	2.97	2.05−4.29	3.14	2.03−4.88	< 0.001
Dialysis	16 (3.5%)	35 (14.1%)	< 0.001	4.55	2.46−8.40	4.82	2.02−11.46	< 0.001
Mechanical ventilation	172 (37.3%)	143 (57.4%)	< 0.001	2.27	1.66−3.10	1.83	1.25−2.68	0.002