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. 2021 Mar 5;6(9):2999–3012. doi: 10.1016/j.bioactmat.2021.01.036

Fig. 5.

Fig. 5

Transplantation of hUCMSC sheet preserves cardiac function of ICR mice. (A)Echocardiograph LV long-axis end diastolic/systolic volume images of treatment and MI-only groups at day 28 post-MI. (B, C) Assessment of echocardiograph LV long-axis EF and FS before MI in treatment and MI-only groups at days 7 and 28 post-MI (control group, n = 6; MI-only group, n = 16; suspension groups, n = 8; cell sheet group, n = 16); values are means (solid line) ±SD (shadow). (D) Peak of the mitral early (E)/late (A)ventricular filling velocity images in treatment and MI-only groups at day 28 post-MI. (E) Quantitative analysis of mitral E/A peak ratio; values are means ± SD (control group, n = 6; MI-only group, n = 8; suspension groups,n = 8; cell sheet group, n = 8). (F–I) Quantitative analysis of radial/longitudinal strain and strain rate; values are means ± SD (control group, n = 5; MI-only group, n = 11; suspension groups, n = 8; cell sheet group, n = 11).*** and NScell sheet group (blue) > cell suspension group (purple) with EF and FS at day 7 post-operatively (P < 0.001 and P > 0.05); *** and **Cell sheet group (blue) > cell suspension group (purple) with EF and FS atday 28 post-operatively (P < 0.001 and P < 0.001); **cell sheet group (blue) > cell suspension group (purple) with FS at day 28 post-operatively (P < 0.01); NScell sheet group (blue) with EF and FS at days 7 and 28 post-operatively (P > 0.05); ** and *cell suspension group (purple) with EF and FS at days 7 and 28 post-operatively (P < 0.01 and P < 0.05); two-way ANOVA with LSD comparison test (B, C); *cell sheet group (blue) > cellsuspension group (purple) with mitral E/A peak ratio (P < 0.05); Kruskal–Wallis H test with Bonferroni correction (E); *cell sheet group (blue) > MI-only group (red) with radial strain (P < 0.05); *cell sheet group (blue) < MI-only group (red) with longitudinal strain rate (P < 0.05); Kruskal–Wallis H test with Bonferroni correction (F, I); *cell sheet group (blue) < MI-only group (red) with longitudinal strain (P < 0.05); Welch ANOVA with Games–Howell comparison test (G); NScell sheet group (blue) > MI-only group (red) with radial strain rate (P > 0.05); one-way ANOVA with Tukey comparison test (H). hUCMSC, human umbilical cord mesenchymal stem cell; LV,left ventricular; MI, myocardial infarction; Sus, suspension; EF, ejection fraction; FS, fractional shortening; SD, standard deviation; ANOVA, analysis of variance; LSD, least significant difference. (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)