Table 2.
Laboratory and Radiographic Findings on the Day of Admission to the Hospital and Hydroxychloroquine Treatment
| All Patients (n = 157) | Negative Conversion Rate | p-value* | ||
| < 14 Days (n = 89) | ≥ 14 Days (n = 68) | |||
| Laboratory findings | ||||
| WBC x 103/mm3, median | 6.60 | 7.10 | 6.40 | 0.155 |
| WBC < 4 x 103/mm3 | 19 (12.1%) | 10 (11.2%) | 9 (13.2%) | 0.703 |
| WBC > 11 x 103/mm3 | 10 (6.4%) | 6 (6.7%) | 4 (5.9%) | 0.827 |
| Neutrophils x 103/mm3, median | 3.63 | 4.14 | 3.38 | 0.043 |
| Neutrophils <1500/mm3 | 8 (5.1%) | 4 (4.5%) | 4 (5.9%) | 0.695 |
| Neutrophils >7000/mm3 | 15 (9.6%) | 14 (15.7%) | 4 (5.9%) | 0.047 |
| Lymphocytes x 103/mm3, median | 1.98 | 2.05 | 1.82 | 0.168 |
| Lymphocytes <1000/mm3 | 8 (5.1%) | 7 (7.9%) | 1 (1.5%) | 0.071 |
| Lymphocytes >3000/mm3 | 28 (17.8%) | 17 (19.1%) | 11 (16.2%) | 0.635 |
| Hemoglobin g/dl, median | 13.70 | 13.80 | 13.45 | 0.358 |
| Low Hb < 13g/dl | 55 (35%) | 28 (31.5%) | 27 (39.7%) | 0.283 |
| Platelets x 103/mm3, median | 213.00 | 218.00 | 210.50 | 0.551 |
| Serum creatinine µmol/l, median | 62.00 | 62.00 | 58.50 | 0.807 |
| ALT u/l, median | 15.20 | 16.50 | 15.00 | 0.872 |
| AST u/l, median | 20.00 | 20.00 | 20.10 | 0.904 |
| Serum albumin g/l, median | 46.00 | 46.00 | 46.25 | 0.794 |
| CRP mg/l, median (n = 148) | 2.45 | 1.85 | 2.93 | 0.021 |
| High CRP (>4 mg/l) | 53 (35.8%) | 23 (28.4%) | 30 (44.8%) | 0.039 |
| ESR mm/h, median (n = 142) | 15.00 | 15.00 | 16.00 | 0.623 |
| High ESR (>20 mm/h) | 55 (38.7%) | 29 (37.7%) | 26 (40%) | 0.776 |
| D-dimer µg/mL, median (n = 146) | 0.98 | 1.00 | 0.95 | 0.867 |
| Positive D-dimer (≥ 1 µg/mL) | 72 (49.3%) | 43 (51.2%) | 29 (46.8%) | 0.598 |
| LDH U/L, median (n = 122) | 434.00 | 437.00 | 431.00 | 1.000 |
| High LDH (> 280 U/L) | 117 (95.9%) | 75 (97.4%) | 42 (93.3%) | 0.274 |
| Radiological findings (n = 122) | ||||
| Abnormal chest radiograph | 38/122 (31.1%) | 12/70 (17.1%) | 26/52 (50%) | <0.001 |
| Unilateral patchy infiltrates | 15 (39.5%) | 7 (58.3%) | 8 (30.8%) | 0.106 |
| Bilateral patchy infiltrates | 23 (60.5%) | 5 (41.7%) | 18 (69.2%) | |
| Treatment (hydroxychloroquine) | 0.749 | |||
| Yes | 137 (87.3%) | 77 (86.5%) | 60 (88.2%) | |
| No | 20 (12.7%) | 12 (13.5%) | 8 (11.8%) | |
Note: *A p-value of less than 0.05 was considered statistically significant as indicated in bold.
Abbreviations: WBC, white blood cells count; Hb, hemoglobin; ALT, alanine aminotransferase; AST, aspartate aminotransferase; CRP, C-reactive protein; ESR, erythrocyte sedimentation rate; LDH, lactate dehydrogenase.