Table 2.
MIC/MBC (μM) Valuesa of Group 2 Analogues with Aromatic or Aliphatic Thiol Ligands
| A. baumannii NCTC 13420 | P. aeruginosa NCTC 13437 | E. cloacae NCTC 13405 | K. pneumoniae ATCC 700603 | S. aureus JE2 (USA300) | E. faecium ATCC 700221 | E. coli ATCC 25922 | log P | |
|---|---|---|---|---|---|---|---|---|
| 1 | 47 (47) | 377 (377) | 189 (189) | 377 (377) | 0.04 (0.09) | 0.2/0.09 (0.4) | 24 (24) | 0.56 |
| 15f | 19/75 (>603) | 302 (302) | 75 (603) | >603 | 0.02 (0.6) | 0.6 (1) | 151 (151) | 2.20 |
| 16g | 18/36 (18) | 291 (291) | 18/73 (36/73) | 146 (146) | 0.009 (0.6) | 0.02 (0.1) | 36 (36) | 0.61 |
| 17d | 18 (18) | 146 (146) | 36 (36) | 36 (36) | 0.07/0.02 (0.07) | 0.02 (0.1) | 9 (9) | 1.36 |
| 18f | 35 (35) | 282 (282) | 141 (141) | 141 (141) | 0.02 (0.3) | 0.02/0.1 (0.3) | 35 (35) | 2.01 |
| 19e | >546 | >546 | >546 | >546 | 0.0004/0.02 (0.02) | 0.06/0.1 (0.5) | >546 | >3.28 |
| 20e | 520 (>520) | >520 | >520 | >520 | 0.02/0.1 (0.2) | 0.02 (0.2) | >520 | >3.18 |
| 21e | 10 (82) | 41 (41) | 5/10 (82) | 20 (20) | 0.03 (0.03) | 0.2/0.3 (0.6) | 10 (10) | 1.19 |
| 22d | 19 (76) | 305 (305) | 38 (152) | 76 (76) | 0.005/0.02 (0.02) | 0.1/0.3 (0.6) | 76 (76) | 1.75 |
| 23g | 37/74 (149) | 149 (149) | 37 (149) | 149 (149) | 0.009 (0.1) | 0.6 (1) | 74 (74) | 2.08 |
a
Assays were repeated twice. Only one value is presented, unless both data are shown.
b
Lowest precipitation concentration at 4 μg/mL.
c
Lowest precipitation concentration at 8 μg/mL.
d
Lowest precipitation concentration at 16 μg/mL.
e
Lowest precipitation concentration at 32 μg/mL.
f
Lowest precipitation concentration at 64 μg/mL.
g
Lowest precipitation concentration at 128 μg/mL.