Table 4.
MIC/MBC (μM) Valuesa of Analogues with Trimethylphosphine Ligands
| A. baumannii NCTC 13420 | P. aeruginosa NCTC 13437 | E. cloacae NCTC 13405 | K. pneumoniae ATCC 700603 | S. aureus JE2 (USA300) | E. faecium ATCC 700221 | E. coli ATCC 25922 | log P | |
|---|---|---|---|---|---|---|---|---|
| 1 | 47 (47) | 377 (377) | 189 (189) | 377 (377) | 0.04 (0.09) | 0.2/0.09 (0.4) | 24 (24) | 0.56 |
| 31g | 6/13 (101) | 101 (101) | 3 (3) | 13 (13) | 0.09 (0.2) | 0.2/0.4(0.8) | 6(6) | 0.35 |
| 37 | 17/4 (17) | >547 | 4/9 (17) | 34 (34) | 0.3/0.5 (1) | 0.3/0.5 (0.5) | 9 (9) | −1.63 |
| 38 | 17/9 (17) | >547 | 4(4) | 34 (34) | 0.3 (0.3) | 0.3/0.5 (0.5) | 9 (9) | −1.88 |
| 39 | 16/8 (16) | >503 | 8/16 (16) | 31 (126) | 0.5 (0.5) | 0.2/0.5 (0.5) | 8/31 (31) | −2.03 |
| 40f | 6/3 (23) | 23/91 (91) | 3 (3) | 11 (23) | 0.3 (0.7) | 0.3 (0.3) | 1/6 (11) | −0.15 |
a
Assays were repeated twice. Only one value is presented, unless both data points are shown.
b
Lowest precipitation concentration at 4 μg/mL.
c
Lowest precipitation concentration at 8 μg/mL.
d
Lowest precipitation concentration at 16 μg/mL.
e
Lowest precipitation concentration at 32 μg/mL.
f
Lowest precipitation concentration at 64 μg/mL.
g
Lowest precipitation concentration at 128 μg/mL.