TABLE 1.
Demographic and clinicopathologic characteristics of the HGSOC patients (TCGA; n = 411)
| Clinicopathologic parameters | Frequency (%) | Immune‐specific subtypes | P | ||
|---|---|---|---|---|---|
| Activated | CAFs | Inactivated | |||
| Age (y) | .10 | ||||
| > 60 | 183 (45) | 64 | 45 | 74 | |
| ≤ 60 | 228 (55) | 99 | 39 | 90 | |
| Ethnicity | .06 | ||||
| Hispanic or Latino | 9 (2) | 7 | 0 | 2 | |
| Non‐Hispanic or Latino | 237 (58) | 93 | 55 | 89 | |
| Missing | 165 (40) | 63 | 29 | 73 | |
| Race | .66 | ||||
| White | 362 (88) | 143 | 76 | 143 | |
| Asian | 13 (3) | 7 | 1 | 5 | |
| Others | 24 (6) | 8 | 4 | 12 | |
| Missing | 12 (3) | 5 | 3 | 4 | |
| Neoplasm grade | .23 | ||||
| G1 + G2 | 48 (12) | 15 | 14 | 19 | |
| G3 + G4 | 355 (86) | 144 | 69 | 142 | |
| Missing | 5 (2) | 1 | 1 | 3 | |
| Stage | .919 | ||||
| I + III | 347 (84) | 136 | 72 | 139 | |
| IV | 61 (15) | 25 | 11 | 25 | |
| Missing | 3 (1) | 2 | 1 | 0 | |
| Lymphovascular invasion | .07 | ||||
| No | 55 (13) | 20 | 7 | 28 | |
| Yes | 104 (25) | 48 | 22 | 34 | |
| Missing | 252 (62) | 95 | 55 | 102 | |
| Vascular invasion | .03 a | ||||
| No | 47 (11) | 19 | 4 | 24 | |
| Yes | 64 (16) | 28 | 16 | 20 | |
| Missing | 300 (73) | 116 | 64 | 120 | |
| Residual disease | .03 a | ||||
| No macroscopic disease | 73 (18) | 27 | 7 | 39 | |
| 1‐20 mm | 220 (54) | 82 | 52 | 86 | |
| >20 mm | 74 (18) | 30 | 19 | 25 | |
| Missing | 44 (10) | 24 | 6 | 14 | |
| Treatment outcome | .18 | ||||
| Complete remission/response | 233 (57) | 98 | 39 | 96 | |
| Partial remission/response | 46 (11) | 14 | 15 | 17 | |
| Progressive disease | 31 (7) | 15 | 7 | 9 | |
| Stable disease | 23 (6) | 7 | 5 | 11 | |
| Missing | 78 (19) | 29 | 18 | 31 | |
| Disease‐free status | .75 | ||||
| Disease‐free | 87 (21) | 34 | 15 | 38 | |
| Recurred/progressed | 260 (63) | 102 | 54 | 104 | |
| Missing | 64 (16) | 27 | 15 | 22 | |
| Primary tumour site | .14 | ||||
| Left | 55 (13) | 30 | 8 | 17 | |
| Right | 45 (11) | 18 | 6 | 21 | |
| Bilateral | 286 (70) | 107 | 62 | 117 | |
| Missing | 25 (6) | 8 | 8 | 9 | |
| Platinum status | .66 | ||||
| Too early | 50 (12) | 24 | 6 | 20 | |
| Resistant | 70 (17) | 25 | 14 | 31 | |
| Sensitive | 164 (40) | 66 | 31 | 67 | |
| Missing | 127 (31) | 48 | 33 | 46 | |
a
Fisher's exact test P < 0.05.