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. 2021 Jan 28;54(3):e12977. doi: 10.1111/cpr.12977

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© 2021 The Authors. Cell Proliferation Published by John Wiley & Sons Ltd.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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A schematic representation of exosomal tsRNAs in regulating a variety of cells and diseases. tsRNAs could inhibit the growth of Fusobacterium nucleatum in the oral cavity. In addition, tsRNAs were significantly increased in exosomes isolated from the blood of liver cancer patients. tRFs in EVs had the potential to regulate immune response by affecting T‐cell activation. Exosomal tsRNAs released by Schistosoma mansoni could regulate gene expression of eukaryotic cells. Besides, 5ʹ tiRNA‐Gly can convey stress‐related signals between adjacent MCF‐7 cells