TABLE 1.
The classification of tsRNAs
| tsRNAs | Category | Length (nts) | Nucleases | Cleavage sites | REFERENCES |
|---|---|---|---|---|---|
| tiRNAs | 5′‐tiRNAs | 28‐36 |
ANG (mammals) RNY1 (yeast) |
The anti‐codon loop of mature tRNA | 43, 44 |
| 3′‐tiRNAs | |||||
| tRFs | tRF‐5a | 14‐16 | Dicer (mice, Drosophila and Schizosaccharomyces. pombe) | D‐loop or the stem region between D‐loop and anti‐codon loop of mature tRNAs | 48, 49 |
| tRF‐5b | 22‐24 | ||||
| tRF‐5c | 28‐30 | ||||
| tRF‐3a | ~18 | ANG (human) | TΨC loop of mature tRNAs | 48, 50, 51 | |
| tRF‐3b | ~22 | ||||
| tRF‐1 | 15‐ 32 | RNase Z or ELAC2 (human) | Near the 3′‐ends of pre‐tRNAs | 23, 51, 52, 53 | |
| tRF‐2 | 15‐ 32 | NA | NA | 54, 55 | |
| i‐tRF | 15‐ 32 | NA | NA | 55 |
Abbreviation: NA, not acquired.