Table 1.
Author (year) [Reference] | Population | Central 0.95 reference interval, nmol/L | Additional information |
---|---|---|---|
Allen 1990 [10] | Healthy U.S. middle-aged adults | 73–271 | Men and women, n=50; 18–65 y |
Rasmussen 1990 [11] | Healthy Danish middle-aged adults | 50–370 | Men and women, n=58; 40–68 y (median: 53 y) |
Rasmussen 1996 [4] | Healthy Danish middle-aged adults before and after vitamin B-12 supplementation for 1 wk (in a few cases for 2 wk) | 80–280 | Men (n=109) and women (n=126); 20–84 y (men; median: 50 y) and 20–85 y (women; median: 49 y); all but 1 subject had plasma creatinine concentrations within the reference interval for healthy subjects |
Joosten 1996 [5] | Healthy Belgian, Dutch, and German middle-aged adults Healthy Dutch elderly living at home Healthy German elderly after B-vitamin supplementation for 3 wk |
62–247 72–476 55–278 |
Men and women, n=99; 19–55 y (mean: 30 y) Men and women, n=64; 65–88 y (mean: 76 y); no participant had creatinine clearance <30 mL/min Men and women, n=143; 65–96 y (mean: 75 y); no participant had creatinine clearance <30 mL/min |
Lewerin 2003 [12] | Swedish elderly with and without B-vitamin supplementation Total study group at baseline Healthy elderly at baseline Healthy elderly after B-vitamin supplementation for 4 mo |
110–480 120–380 20–340 |
Men and women, n=209; 70–88 y (women) and 70–93 y (men) (overall median: 76 y) n=208 n=123 n=78 (vitamin B-12 replete) |
Milman 2007 [13] | Healthy Danish pregnant women 18 wk gestation 32 wk gestation 39 wk gestation 8 wk post-partum |
40–290 50–340 60–360 80–350 |
Women (n=434) with a normal pregnancy ≥37 wk n=413 n=390 n=250 n=160 |
Vogiatzoglou 2009 [14] | Norwegian middle-aged adults: Unselected Vitamin B-12 ≥200 pmol/L Vitamin B-12 ≥400 pmol/L Norwegian elderly: Unselected Vitamin B-12 ≥200 pmol/L Vitamin B-12 ≥400 pmol/L |
100–320 100–300 100–280 110–490 110–410 100–360 |
Men and women, n=3,684; 47–49 y n=3,684 n=3,568 n=1,306 (vitamin B-12 replete) Men and women, n=3,262; 71–74 y n=3,262 n=3,043 n=1,058 (vitamin B-12 replete) |
Erdogan 2010 [6] | Healthy US adults US persons tested for MMA (unknown clinical history) 0–10 y 11–20 y 21–30 y 31–40 y 41–50 y 51–60 y 61–70 y ≥71 y |
60–360 0–510 30–260 50–330 50–400 50–400 50–420 50–440 50–480 |
Men (n=16) and women (n=24) Males and females (n=4,944); highest 10% of results disregarded (potentially unhealthy persons) n=28 n=39 n=165 n=287 n=545 n=813 n=918 n=2149 |