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. Author manuscript; available in PMC: 2022 Feb 1.
Published in final edited form as: Genes Brain Behav. 2020 May 29;20(2):e12666. doi: 10.1111/gbb.12666

Figure 4. Model used to describe COC and metabolites, NOR and BZE, in plasma (PL) and brain (BR).

Figure 4.

COC, NOR, and BZE were each presented in a population PK model, with COC undergoing Michaelis Menten kinetics in plasma forming NOR and BZE. All COC, NOR, and BZE undergo bidirectional transport process entering and exiting the brain. NOR and BZE are also formed in the brain from COC entered through the plasma. Abbreviations and definitions: CPL, NOR, NOR concentration in plasma; VPL, NOR, NOR volume of distribution in plasma; QPLNOR-BRNOR, NOR flow rate between plasma and brain; ClPLNOR, out, NOR clearance from plasma; VmaxNOR, maximum rate of NOR formation from COC in plasma; KmNOR, Michaelis-Menten constant for NOR formation in plasma; CBR, NOR, concentration of NOR in the brain; VBR, NOR, volume of distribution of NOR in the brain; KBRCOC-BRNOR, formation rate constant of NOR from COC in the brain; QPLCOC-tissue, flow rate of COC between plasma and tissue; ClPLCOC, out, COC clearance from plasma; CPL, COC, COC concentration in plasma; VPL, COC, COC volume of distribution in plasma; QPLCOC-BRCOC, flow rate of COC between plasma and brain; CBR, COC, COC concentration in the brain; VBR, COC, COC volume of distribution in the brain; KBRCOC-BRBZE, formation rate constant of BZE form cocaine in the brain; CBR, BZE, concentration of BZE in the brain; VBR, BZE, volume of distribution of BZE in the brain; QPLBZE-BRBZE, flow rate of BZE between plasma and brain; CPL,BZE, concentration of BZE in plasma; VPL, BZE, volume of distribution of BZE in plasma; ClPLBZE, out, plasma clearance of BZE; VmaxBZE, maximum rate of BZE formation from cocaine in plasma; KmBZE, Michaelis-Menten constant for BZE formation in plasma.