Skip to main content
. Author manuscript; available in PMC: 2022 Feb 1.
Published in final edited form as: Genes Brain Behav. 2020 May 29;20(2):e12666. doi: 10.1111/gbb.12666

Table 3. Descriptive results of dose response stratified by strains.

Stratified by strain, major PD parameters are summarized for ambulatory movement in relation to time from 0–30 min post cocaine injection at dose indicated. Values were adjusted for saline administration by subtracting the mean distance travelled for animals in the saline group.

Strain Dose
(mg/kg)
Tmax-PD
(min)
CV% Rmax
(cm/min)
CV% Total 30 min Distance
(cm)
CV%
I/LnJ 5 10 36.89 399.23 26.22 5788.7 83.87
10 5 32.27 1211.73 19.05 19820.39 38.95
30 10 35.90 1132.87 16.53 16277.36 48.32
40 15 57.74 1078.3 19.93 18122.33 54.23
C57BL/6J 5 5 53.56 143.23 37.98 3273.18 86.82
10 5 56.71 441.41 39.99 9036.48 56.50
30 15 33.92 1236.41 23.81 28610.7 30.28
40 15 39.59 1135.42 27.27 27040.53 39.05
FVB/NJ 5 15 67.19 119.23 18.06 2678.24 64.81
10 30 56.66 382.95 31.24 8888.3 71.42
30 10 28.75 594.29 57.16 12628.77 94.71
40 30 40.16 476.75 44.99 9647.44 95.83
BTBR T+tf/J 5 5 96.26 134.26 65.78 1664.85 241.18
10 2 80.55 232.85 40.29 2227.07 153.37
30 20 49.72 605.26 54.44 13238.46 75.22
40 20 52.56 673.58 56.10 15027.21 83.32
LG/J 5 5 99.17 30.64 67.39 −2364.42 95.44
10 2 82.65 146.74 67.01 −432 1104.34
30 2 93.60 145.25 70.96 −600.81 665.26
40 2 84.88 127.37 82.09 865.08 744.69
LP/J 5 2 84.18 −20.78 35.95 −1657.83 47.12
10 15 49.31 103.55 77.40 476.67 742.99
30 15 34.29 595.38 40.20 11649.02 61.66
40 10 57.36 534.76 52.67 10829.67 92.31