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. 2021 Jan 29;11:615543. doi: 10.3389/fphar.2020.615543

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Copyright © 2021 Lan, Liu, Juan, Zhang, Ma, Xie, Sun, Feng, Sun and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Spatial learning and memory ability of rats in Morris water maze test. (A) swimming speed; (B) escape latency; (C) swimming distance on the sixth day; (D) crossing times; (E) time spent in the target quadrant; (F) the representative trajectory diagrams (1, 2, 3, 4: four different quadrants; Blue dots: starting position; Red dots: ending position; Small yellow circles: the previous location of the platform.); Values are presented as the mean ± standard deviation. *p < 0.05 vs. Con group; ^# p < 0.05 vs. LPS group (n = 10 in each group). LPS induced the expression of TSPO in the hippocampus, PK11195 attenuate this response.