TABLE 4.
Results of the network meta-analysis of leukopenia (upper-right quarter) and hemoglobin reduction (lower left quarter).
| ADI + NP | 3.22 (2.39.4.39) | 1.59 (0.37.6.61) | 0.92 (0.52.1.63) | 0.90 (0.32.2.48) | 0.90 (0.35.2.27) | 1.34 (0.78.2.32) | 0.93 (0.53.1.68) | 1.17 (0.67.1.99) | 0.93 (0.49.1.75) | 1.13 (0.56.2.27) | 0.64 (0.35.1.18) | 0.92 (0.53.1.62) | 1.31 (0.34.4.95) |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1.78 (1.13,2.79) | NP | 0.49 (0.12.1.98) | 0.29 (0.17,0.46) | 0.28 (0.10,0.73) | 0.28 (0.11,0.66) | 0.42 (0.27,0.65) | 0.29 (0.18,0.47) | 0.36 (0.22,0.56) | 0.29 (0.16,0.50) | 0.35 (0.18,0.66) | 0.20 (0.12,0.34) | 0.29 (0.18,0.46) | 0.41 (0.11.1.47) |
| − | − | AI + NP | 0.58 (0.13.2.63) | 0.56 (0.10.3.17) | 0.56 (0.11.3.07) | 0.84 (0.20.3.83) | 0.58 (0.13.2.69) | 0.73 (0.17.3.31) | 0.58 (0.13.2.72) | 0.71 (0.15.3.42) | 0.40 (0.091.1.87) | 0.58 (0.13.2.65) | 0.82 (0.12.5.69) |
| 0.80 (0.33.1.90) | 0.45 (0.21,0.94) | − | CKSI + NP | 0.98 (0.32.2.88) | 0.98 (0.36.2.66) | 1.45 (0.76.2.87) | 1.006 (0.51.2.05) | 1.27 (0.65.2.45) | 1.007 (0.48.2.12) | 1.22 (0.55.2.73) | 0.70 (0.34.1.44) | 1 (0.51.1.98) | 1.42 (0.35.5.67) |
| 0.081 (0.013,0.37) | 0.046 (0.0076,0.19) | − | 0.10 (0.015,0.52) | DLSI + NP | 1 (0.27.3.76) | 1.49 (0.52.4.49) | 1.034 (0.35.3.13) | 1.30 (0.44.3.84) | 1.033 (0.34.3.23) | 1.26 (0.39.4.09) | 0.72 (0.24.2.18) | 1.027 (0.35.3.096) | 1.46 (0.28.7.46) |
| − | − | − | − | − | HCSI + NP | 1.49 (0.56.4.04) | 1.033 (0.38.2.86) | 1.30 (0.48.3.47) | 1.032 (0.37.2.93) | 1.25 (0.42.3.74) | 0.72 (0.26.2.009) | 1.026 (0.38.2.78) | 1.46 (0.30.6.86) |
| 0.85 (0.42.1.71) | 0.48 (0.28,0.81) | − | 1.055 (0.43.2.69) | 10.48 (2.25,68.98) | − | JOEI + NP | 0.69 (0.36.1.35) | 0.87 (0.45.1.62) | 0.69 (0.34.1.40) | 0.84 (0.38.1.81) | 0.48 (0.24,0.96) | 0.69 (0.36.1.31) | 0.97 (0.24.3.81) |
| 0.91 (0.35.2.39) | 0.51 (0.21.1.20 | − | 1.14 (0.36.3.62) | 11.16 (2.046,82.62) | − | 1.076 (0.38.2.93) | KAI + NP | 1.26 (0.62.2.41) | 1 (0.47.2.083) | 1.21 (0.54.2.69) | 0.70 (0.33.1.42) | 0.99 (0.5.1.94) | 1.41 (0.34.5.56) |
| − | − | − | − | − | − | − | − | KLTI + NP | 0.79 (0.39.1.66) | 0.96 (0.45.2.13) | 0.55 (0.28.1.12) | 0.79 (0.42.1.54) | 1.12 (0.28.4.49) |
| 1.038 (0.47.2.23) | 0.58 (0.30.1.08) | − | 1.29 (0.48.3.53) | 12.69 (2.61,84.04) | − | 1.22 (0.53.2.76) | 1.12 (0.39.3.32) | − | SFI + NP | 1.21 (0.52.2.83) | 0.69 (0.32.1.51) | 1 (0.48.2.073) | 1.41 (0.34.5.78) |
| 0.66 (0.22.1.96) | 0.37 (0.14,0.99) | − | 0.82 (0.23.2.92) | 8.30 (1.4,63.03) | − | 0.78 (0.26.2.36) | 0.73 (0.20.2.59) | − | 0.64 (0.20.2.076) | SGMI + NP | 0.57 (0.25.1.30) | 0.82 (0.37.1.81) | 1.16 (0.27.4.89) |
| 0.50 (0.19.1.25) | 0.28 (0.12,0.63) | − | 0.61 (0.20.1.89) | 6.039 (1.12,40.72) | − | 0.58 (0.22.1.52) | 0.54 (0.16.1.85) | − | 0.47 (0.17.1.37) | 0.75 (0.21.2.69) | SMI + NP | 1.43 (0.71.2.90) | 2.022 (0.49.8.25) |
| 0.76 (0.39.1.50) | 0.43 (0.25,0.72) | − | 0.95 (0.39.2.43) | 9.41 (1.98,60.17) | − | 0.89 (0.43.1.89) | 0.83 (0.31.2.34) | − | 0.73 (0.33.1.68) | 1.15 (0.39.3.52) | 1.55 (0.57.4.23) | SQFZI + NP | 1.41 (0.35.5.62) |
| 0.84 (0.24.2.79) | 0.47 (0.14.1.43) | − | 1.047 (0.26.4.051) | 10.17 (1.62,86.22) | − | 0.98 (0.27.3.47) | 0.92 (0.21.3.96) | − | 0.81 (0.21.2.96) | 1.26 (0.28.5.60) | 1.67 (0.41.7.11) | 1.10 (0.30.3.76) | XAPI + NP |
Note: The differences between the compared groups were deemed as significant when the 95% CI of the OR did not contain 1.00, which is marked as bold font. ADI, Aidi injection; AI, Astragalus injection; CSI, Chansu injection; CKSI, Compound kushen injection; DLSI, Delisheng injection; HCSI, Huachansu injection; JOEI, Javanica oil emulsion injection; KAI, Kangai injection; KLTI, Kanglaite injection; NP, vinorelbine plus cisplatin; SFI, Shenfu injection; SMI, Shenma injection; SQFZI, Shenqifuzheng injection; SGMI, Shengmai injection; XAPI, Xiaoaiping injection.