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. 2021 Mar 9;18:10. doi: 10.1186/s12976-021-00140-3

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — The number of COVID-19 cases (panel A), prevalence of the amino acids (AA) on the 614-th codon of the S protein (panel B), and time-varying reproduction number (R_t, panel C) in California from March to April 2020. Panel A shows the daily number of COVID-19 time series. Panel B shows the prevalence of the AAs, including Aspartic Acid (D, in cyan) and Glycine (G, in purple), on the 614-th codon of the S protein. Panel C shows the R_t estimated (black) from the number of cases data using renewable equation and fitted (red) by using the mutation activity on the 614-th codon of the S protein in panel B. In each panel, the vertical dashed blue line represents the date, March 19, when the ‘stay-at-home’ order was officially implemented in California