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. 2019 Jan 16;2(4):e1155. doi: 10.1002/cnr2.1155

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© 2019 The Authors Cancer Reports Published by Wiley Periodicals, Inc.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Proportion of cells with intracellular agent in MDA‐468, IGROV‐1, and TK10 carcinoma cell lines and MRC‐5 fibroblasts determined as number of cells with detectable fluorescence of the agent. Cells treated with 1μM concentration of test agent for 3 and 9 h. Results are shown for test agents A, GW 610 and AFt‐GW 610 and B, GW 608‐Lys and AFt‐GW 608‐Lys. Data points are mean ± standard deviation (SD), from three independent trials. For sensitive carcinoma cell lines significant enhancement on uptake is observed for Lys‐conjugated agent compared with insensitive MRC‐5 cells (P < 0.001; exemplified also in Figure S7)