Figure 1.

Glioblastoma tumor structure and heterogeneity. The tumor is comprised of several cell types including GBSC positive for Nestin, NANOG, OCT4, PROM1, and KLF4; proliferating cells positive for PCNA and AGNOR; astrocytes positive for GFAP and vimentin; immune cells positive for Iba‐1, CD68, and CD3; endothelial cells positive for CD31 von Willebrand factors and CD99; fibroblast positive for TE‐7 and SMA; and neurons positive for MAP‐2 or neuN. Most of these areas are repetitive and with multiple mutations. Thus, the heterogeneity of the tumor is extremely high