Figure 2.

Metabolic alterations observed in CLL cells. A, Flux through glutaminolysis is increased as evidenced by decreased Gln and Glu, elevated ala, and increased expression of glutaminase and glutamine synthetase. Coculturing with stroma increases TCA cycle activity in CLL cells. B‐CLL cells have lower levels of cystine and the xCT cystine transporter; experimental evidence suggests that the stroma can regulate CLL redox homeostasis by reducing the cystine disulfide to cysteine, which enters cells and is utilized for glutathione biosynthesis