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Metabolic features of AML cells. A, Mutant isocitrate dehydrogenase (IDH) generates oncometabolite (R)‐2‐hydroxyglutarate from a‐ketoglutarate. B, Hallmarks of drug‐resistant AML cells include a reliance on glutamine to fuel glutathione (GSH) biosynthesis and pyrimidine synthesis. Additionally, drug‐resistant cells have elevated pentose phosphate pathway (PPP) activity particularly of rate‐limiting enzyme glucose 6‐phosphate dehydrogenase (G6PDH)
