Table 2.

Risk of death in S gene negative compared with S gene positive (reference category) participants

Model, predictor, value	Hazard ratio (95% CI)	P value
S gene+age
S gene status:
Positive (ref)	—	—
Negative	1.64 (1.32 to 2.04)	<0.001
Age (per decade)	3.55 (3.28 to 3.84)	<0.001
S gene+N gene cycle threshold+age
S gene status:
Positive (ref)	—	—
Negative	1.37 (1.09 to 1.72)	0.004
Age (per decade)	3.51 (3.24 to 3.80)	<0.001
N gene cycle threshold (per 10 units)	0.50 (0.39 to 0.65)	<0.001

Hazard ratios >1 are indicative of an increased rate of death in people with infections compatible with VOC-202012/01. In the first model the S gene status is assessed as an indicator with age as a covariate, in the second model variability is included in the N gene cycle threshold value measured in the original specimen as a continuous predictor.