Figure 2. LCB1-Fc prophylaxis prevents SARS-CoV-2-mediated lung disease.

(A) Respiratory mechanics parameters: inspiratory capacity, resistance, elastance tissue damping, quasi-static compliance, and pressure-volume loops measured at 7 dpi (n = 3–6, two experiments: two-way ANOVA with Tukey’s post-test: ns, not significant, * P < 0.05, ** P < 0.01, *** P < 0.001 between indicated groups). (B) Hematoxylin and eosin staining of lung sections from mice treated at D-1 and collected at 7 dpi with SARS-CoV-2. Images show low (left) and high (right; boxed region from left) magnification. Scale bars for all images, 100 μm. Representative images from n = 3 mice per group. (C) Heat-map of cytokine mRNA levels from lung tissues of SARS-CoV-2 infected mice at 4 dpi. For each cytokine, the fold-change was calculated relative to age-matched naïve control animals after normalization to Gapdh and the Log₂(fold change) was plotted (n = 8 mice/group relative to n = 3 naïve controls).