3. Age-specific incidence trends in CRC between Republic of Korea, Canada and China.

Country	Age group (year)	Trend 1			Trend 2			2003−2012 AAPC (95% CI) (%)
		Period	APC (95% CI) (%)		Period	APC (95% CI) (%)
CRC, colorectal cancer; APC, annual percentage change; AAPC, average annual percentage change; 95% CI, 95% confidence interval; *, P<0.05.
Male
China	30−39	2003−2012	0.1 (−3.0, 3.2)					0.1 (−3.0, 3.2)
	40−49	2003−2012	0.3 (−1.3, 2.0)					0.3 (−1.3, 2.0)
	50−59	2003−2012	1.8* (0.8, 2.8)					1.8* (0.8, 2.8)
	60−69	2003−2012	0.3 (−0.6, 1.3)					0.3 (−0.6, 1.3)
	70−79	2003−2006	4.1* (0.8, 7.6)		2006−2012	−1.4* (−2.5, −0.3)		0.4 (−0.6, 1.4)
	80+	2003−2012	−0.6 (−1.9, 0.8)					−0.6 (−1.9, 0.8)
Republic of Korea	30−39	2003−2012	6.2* (4.5, 8.0)					6.2* (4.5, 8.0)
	40−49	2003−2005	13.4* (1.5, 26.8)		2005−2012	2.4* (0.9, 3.9)		4.8* (2.6, 7.0)
	50−59	2003−2010	5.4* (3.7, 7.1)		2010−2012	−2.2 (−13.3, 10.3)		3.6* (1.3, 6.0)
	60−69	2003−2012	4.4* (3.1, 5.7)					4.4* (3.1, 5.7)
	70−79	2003−2009	5.9* (4.7, 7.2)		2009−2012	−1.8 (−5.2, 1.7)		3.3* (2.2, 4.4)
	80+	2003−2012	5.5* (3.4, 7.6)					5.5* (3.4, 7.6)
Canada	30−39	2003−2012	4.4* (1.1, 7.9)					4.4* (1.1, 7.9)
	40−49	2003−2012	1.8* (0.9, 2.7)					1.8* (0.9, 2.7)
	50−59	2003−2012	−0.7 (−1.6, 0.1)					−0.7 (−1.6, 0.1)
	60−69	2003−2012	−1.5* (−2.2, −0.7)					−1.5* (−2.2, −0.7)
	70−79	2003−2008	0.2 (−1.2, 1.7)		2008−2012	−4.2* (−6.1, −2.2)		−1.8* (−2.7, −0.8)
	80+	2003−2012	−0.5 (−1.3, 0.2)					− 0.5 (−1.3, 0.2)
Female
China	30−39	2003−2012	1.6 (−2.2, 5.6)					1.6 (−2.2, 5.6)
	40−49	2003−2012	−0.4 (−2.5, 1.7)					−0.4 (−2.5, 1.7)
	50−59	2003−2008	−0.9 (−2.9, 1.2)		2008−2012	2.2 (−0.8, 5.2)		0.5 (−0.8, 1.8)
	60−69	2003−2012	−1.2* (−2.0, −0.4)					−1.2* (−2.0, −0.4)
	70−79	2003−2012	−0.5 (−1.5, 0.4)					−0.5 (−1.5, 0.4)
	80+	2003−2012	0.3 (−0.5, 1.1)					0.3 (−0.5, 1.1)
Republic of Korea	30−39	2003−2012	5.2* (3.2, 7.1)					5.2* (3.2, 7.1)
	40−49	2003−2005	13.8 (−1.4, 31.4)		2005−2012	2.8* (0.9, 4.8)		5.2* (2.4, 8.0)
	50−59	2003−2012	2.5* (1.4, 3.7)					2.5* (1.4, 3.7)
	60−69	2003−2007	6.4* (5.0, 7.9)		2007−2012	0.6 (−0.3, 1.6)		3.2* (2.5, 3.8)
	70−79	2003−2009	4.6* (3.6, 5.6)		2009−2012	0.0 (−2.7, 2.9)		3.1* (2.2, 3.9)
	80+	2003−2012	4.0* (3.3, 4.7)					4.0* (3.3, 4.7)
Canada	30−39	2003−2012	5.3* (1.6, 9.1)					5.3* (1.6, 9.1)
	40−49	2003−2012	2.4* (1.3, 3.6)					2.4* (1.3, 3.6)
	50−59	2003−2012	0.7* (0.3, 1.1)					0.7* (0.3, 1.1)
	60−69	2003−2012	−1.4* (−1.9, −0.9)					−1.4* (−1.9, −0.9)
	70−79	2003−2010	−0.3 (−1.3, 0.7)		2010−2012	−5.6 (−12.6, 1.9)		−1.5* (−2.9, −0.1)
	80+	2003−2012	−0.7* (−1.3, −0.1)					−0.7* (−1.3, −0.1)