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Effector function of IL-1 cytokine. Systemic effect—hypothalamic–pituitary–adrenal axis activation (cortisol production and fever induction), production of acute phase proteins (CRP, SAA, ferritin, complement) and coagulation factors (fibrinogen) production in liver, endothel activation (expression of chemokines and adhesion molecules), local effect—activation of innate immunity (monocytes, neutrophils), adaptive immunity (Th17, CD8) and innate lymphoid cells (ILC3, γδT17).
