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. Author manuscript; available in PMC: 2022 Jan 1.
Published in final edited form as: Adv Ther (Weinh). 2020 Sep 28;4(1):2000088. doi: 10.1002/adtp.202000088

Figure 10.

Figure 10.

Preclinical and clinical investigation of intra-articular (IA) TLC599 for osteoarthritis (OA) therapy. (A) Mean concentration of dexamethasone phosphate (DSP) in canine synovial fluid. (B) Least-squares (LS) mean change from baseline (and standard error [SE]) in Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain subscore on a 0–4 numeric rating scale. (A) reproduced with permission.[163] Copyright 2019, BMJ Publishing Group Ltd. (B) adapted with permission.[168] Copyright 2019, Elsevier Ltd.