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. 2021 Mar 9;14:149. doi: 10.1186/s13071-021-04655-z

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Results of UCP-LF CAA test at baseline and baseline (T0) and follow-up time points (T6 and T12). a Percentage of patients with positive UCP-LF CAA test; error bars represent 95% CI. b Change in UCP-LF CAA levels over time in individual patients; log10 scale (the continuous dashed line indicates the threshold for positivity CAA 1 pg/ml; the interrupted dashed line indicates the threshold for indeterminate result CAA 0.5 pg/ml). c Change in UCP-LF CAA levels over time (the continuous dashed line indicates the threshold for positivity CAA 1 pg/ml; the interrupted dashed line indicates the threshold for indeterminate result CAA 0.5 pg/ml); box and whisker plots indicate median and IQR. Number of investigated patients with each test at each time point is indicated in Fig. 1. ***p ≤ 0.0001