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. 2021 Mar 8;21:78. doi: 10.1186/s12866-021-02125-1

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — a Analysis of Beta diversity revealed significant differences between psoriasis group (P) and healthy control group (N) performed on the unweighted UniFrac (P<0.001). The results revealed a significant separation in the bacterial community composition between psoriasis patients and healthy individual; b PLS-DA plot of OTU. The horizontal axis and the vertical axis indicate the top 2 components. Each dot represents one sample and yellow dots stand for psoriasis group (P) and blue dots stand for healthy control group (N). It revealed significant clustering of psoriasis group (P) and healthy control group (N); c and d The dominant Family and Genus in the psoriasis group (P) and healthy control group (N). Histogram representation of the relative abundance (%) of the main taxa and the significant differences (P-values) observed between two groups. * 0.01 < P-value <= 0.05, ** 0.001 < = P-value <= 0.01; e and f The enriched taxa in psoriasis group (P) and control (N) fecal microbiota were represented in Cladogram. The central point represents the root of the tree (Bacteria), and each ring represents the next lower taxonomic level (phylum to genus: p, phylum; c, class; o, order; f, family; g, genus). The diameter of each circle represents the relative abundance of the taxon. The taxa with no significant differences were colored yellow, the red nodes represented the microbiota that played an important role in the healthy control group (N). The green node represents the microbiome that plays an important role in the psoriasis group (P) .And the most differentially abundant taxa between the psoriasis group (P) and healthy control group (N) which was generated from LEfSe analysis