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. 2021 Mar 9;19:101. doi: 10.1186/s12967-021-02769-7

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Knocking down LncRNA-gm9795 significantly decreased the expression of inflammation factors in NASH: a Interference efficiency of siRNA-gm9795 in MCD+LPS model; b In MCD+LPS model, the mRNA expression of TNF $α$ was decreased after knocking down gm9795; c In MCD+LPS model, the mRNA expression of IL-6 was decreased after knocking down gm9795; d In MCD+LPS model, the mRNA expression of IL-1 $β$ was decreased after knocking down gm9795; e Interference efficiency of siRNA-gm9795 in PA model; f. In PA model, the mRNA expression of TNF $α$ was decreased after knocking down gm9795;g. In PA model, the mRNA expression of IL-6 was decreased after knocking down gm9795; h In PA model, the mRNA expression of IL-1 $β$ was decreased after knocking down gm9795; i Relative gray analysis of protein expression of inflammation factors with gm9795 interference in MCD+LPS model; j The protein expression of inflammation factors was decreased after knocking down gm9795 in MCD+LPS model; k The protein expression of inflammation factors was decreased after knocking down gm9795 in PA model; l Relative gray analysis of protein expression of inflammation factors with gm9795 interference in PA model; (*P < 0.05, **P < 0.01,***P < 0.001)