Fig. 5.

MiR-432-5p reverses the oncogenic effects of circNEIL3 in CFPAC-1 cells. a-b. The expression of miR-432-5p in CFPAC-1 and MiaPaca-2 cells transfected with the miR-432-5p mimics, inhibitor and corresponding NC was detected by RT-qPCR. c-k. CFPAC-1 cells were divided into four groups (circNEIL3 KD NC + miR-432-5p inhibitor NC, KD NC + miR-432-5p inhibitor, circNEIL3 KD + inhibitor NC and circNEIL3 KD + miR-432-5p inhibitor). The proliferation, migration and invasion ability of CFPAC-1 was analyzed through CCK-8, colony formation, EdU, transwell and wound healing assays. The EdU samples were imaged at 200× magnification. Scale bar = 50 μm. The transwell and wound healing images taken at 100× magnification. Scale bar = 100 μm. All data are presented as the means ± SD of three independent experiments. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001