Table 2.
The relationship between miR-1182, miR-let-7a and clinicopathological characteristics of patients with CCA
| Influence factors | miR-1182 | miR-let-7a | ||||
|---|---|---|---|---|---|---|
| High | Low | p value | HIGH | LOW | p value | |
| Gender | ||||||
| Male | ||||||
| 34 | 14 | 20 | 0.289 | 17 | 17 | 0.74 |
| Female | ||||||
| 22 | 6 | 16 | 10 | 12 | ||
| Age | ||||||
| ≥ 55 | ||||||
| 20 | 7 | 13 | 0.934 | 9 | 11 | 0.72 |
| < 55 | ||||||
| 36 | 13 | 23 | 18 | 18 | ||
| Tumor size | ||||||
| ≥ 2 cm | ||||||
| 16 | 6 | 10 | 0.86 | 7 | 9 | 0.672 |
| < 2 cm | ||||||
| 40 | 14 | 26 | 20 | 20 | ||
| TNM stage | ||||||
| I–II | ||||||
| 22 | 17 | 5 | < 0.001 | 18 | 4 | < 0.001 |
| III–IV | ||||||
| 34 | 3 | 31 | 9 | 25 | ||
| Differentiation degree | ||||||
| High | ||||||
| 17 | 15 | 2 | < 0.001 | 15 | 2 | < 0.001 |
| Moderate | ||||||
| 19 | 4 | 15 | 10 | 9 | ||
| Low | ||||||
| 20 | 1 | 19 | 2 | 18 | ||
| LNM | ||||||
| Yes | ||||||
| 27 | 1 | 26 | < 0.001 | 3 | 24 | < 0.001 |
| No | ||||||
| 29 | 19 | 10 | 24 | 5 | ||
The expression of miR-1182 and miR-let-7a was not significantly different from the age, sex and tumor size of patients, but the expression was significantly correlated with patient TNM staging, degree of differentiation and LNM (p < 0.001)
miR-1182 microRNA1182, miR-let-7a microRNA-let-7a, TNM tumor nodes metastasis, LNM lymph node metastasis