Table 2.

HSCR-susceptibility genes that showed an aberrant methylation level in HSCR patients versus controls

	Gene	Seqnames	Start	End	Width	Beta	Pval	Annot,strand	1to5kb	5UTRs	Promoters	Firstexons	Exons	Introns	3UTRs
1	ABO	chr9	133,259,941	133,260,919	979	− 0.858	0.004	−						X
2	ACTN4	chr19	38,647,739	38,647,796	58	0.119	0.033	+		X	X	X	X
3	ADORA2A	chr22	24,427,450	24,427,589	140	0.378	0.036	+	X	X	X	X	X	X
4	AES	chr19	3,057,417	3,059,794	2378	− 0.885	0.001	−	X	X	X	X	X	X
5	AFAP1-AS1	chr4	7,768,658	7,771,115	2458	− 0.647	0.047	+						X
6	AHNAK	chr11	62,538,664	62,539,087	424	− 0.987	0.042	−	X					X
7	AP3B2	chr15	82,703,145	82,703,810	666	− 0.526	0.027	−	X					X
8	ARNT2	chr15	80,435,195	80,437,732	2538	− 0.544	0.047	+	X					X
9	ASCL1	chr12	102,958,457	102,958,690	234	0.124	0.023	+				X	X
10	BCL11B	chr14	99,271,192	99,272,182	991	0.123	0.031	−		X	X	X	X
11	CA3	chr8	85,423,540	85,424,639	1100	− 0.669	0.040	+						X
12	CACNA1C	chr12	2,230,284	2,230,376	93	− 1.031	0.003	+						X
13	CAPN10	chr2	240,589,510	240,589,844	335	0.692	0.039	+	X		X		X	X
14	CHRNA7	chr15	32,060,846	32,060,974	129	− 0.645	0.022	+						X
15	COL6A1	chr21	45,992,053	45,994,972	2920	− 0.258	0.046	+	X				X	X
16	CREBBP	chr16	3,773,849	3,774,877	1029	− 0.530	0.043	−	X		X	X	X	X
17	CTNS	chr17	3,635,527	3,637,759	2233	0.345	0.014	+	X	X	X	X	X	X
18	DBH	chr9	133,642,000	133,642,886	887	− 0.636	0.039	+					X	X
19	DHCR7	chr11	71,440,414	71,442,189	1776	0.413	0.026	−	X		X	X	X	X
20	DSCAM	chr21	40,197,142	40,198,150	1009	− 0.805	0.001	−						X
21	ECE1	chr1	21,290,149	21,290,245	97	0.090	0.039	−		X		X	X	X
22	FAT3	chr11	92,451,580	92,452,675	1096	− 0.605	0.008	+						X
23	FGD2	chr6	37,025,970	37,026,290	321	− 0.411	0.050	+						X
24	GDNF	chr5	37,834,936	37,835,683	748	− 0.649	0.012	−		X	X	X	X	X
25	GFRA1	chr10	116,112,901	116,113,661	761	− 0.479	0.043	−						X
26	GLI2	chr2	120,987,959	120,988,503	545	0.176	0.039	+					X	X	X
27	IHH	chr2	219,055,465	219,055,534	70	− 0.558	0.038	−					X
28	IRS1	chr2	226,796,575	226,797,233	659	0.983	0.019	−	X			X	X
29	ITGB2	chr21	44,886,345	44,888,733	2389	− 0.637	0.006	−				X	X	X	X
30	ITIH5	chr10	7,602,000	7,602,962	963	− 0.737	0.023	−						X
31	KCNH2	chr7	150,958,459	150,958,537	79	− 0.615	0.019	−	X				X	X
32	KCNN3	chr1	154,790,536	154,791,444	909	− 0.735	0.025	−						X
33	LAMA1	chr18	7,109,731	7,109,954	224	− 0.413	0.044	−						X
34	MEG3	chr14	100,824,290	100,824,355	66	− 1.330	0.001	+	X					X
35	MUC4	chr3	195,778,818	195,778,991	174	− 0.499	0.016	−					X	X
36	NLRP12	chr19	53,809,751	53,810,198	448	− 0.729	0.025	−	X				X
37	NLRP3	chr1	247,430,893	247,431,526	634	− 1.075	0.001	+						X
38	NOTCH1	chr9	136,507,039	136,507,083	45	− 0.598	0.038	−	X					X
39	NR2F1	chr5	93,588,640	93,588,660	21	− 1.076	0.004	+	X					X
40	NTF3	chr12	5,452,375	5,453,552	1178	− 0.547	0.017	+	X					X
41	NTRK3	chr15	88,059,303	88,061,553	2251	− 0.788	0.031	−						X
42	PCDHA9	chr5	140,877,089	140,877,155	67	− 0.548	0.016	+						X
43	PTCH1	chr9	95,504,586	95,505,498	913	0.835	0.041	−	X					X
44	RARB	chr3	25,380,243	25,380,308	66	0.959	0.007	+						X
45	RBP3	chr10	47,348,275	47,349,153	879	− 0.821	0.006	+		X	X	X	X
46	RBPMS	chr8	30,441,141	30,441,979	839	− 0.696	0.039	+	X		X			X
47	RPS6KA3	chrX	20,265,270	20,265,640	371	− 0.488	0.007	−						X
48	SH2B1	chr16	28,862,077	28,862,273	197	0.647	0.046	+	X		X			X
49	SIX2	chr2	45,012,355	45,013,494	1140	− 0.739	0.006	−	X			X	X
50	SLC2A1	chr1	42,940,264	42,941,301	1038	0.528	0.043	−						X
51	SOX8	chr16	978,998	980,273	1276	− 0.789	0.008	+	X
52	TERT	chr5	1,292,813	1,293,293	481	− 0.639	0.032	−						X
53	TNC	chr9	115,085,688	115,086,564	877	− 0.600	0.014	−					X	X
54	TST	chr22	37,024,548	37,024,766	219	− 0.305	0.038	−	X
55	ZFHX3	chr16	72,947,027	72,948,255	1229	0.937	0.041	−						X

Genes in bold were hypomethylated (ß < 0), whereas the remaining genes were hypermethylated (ß > 0)