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. Author manuscript; available in PMC: 2021 May 10.
Published in final edited form as: J Control Release. 2020 Jan 28;321:259–271. doi: 10.1016/j.jconrel.2020.01.052

Fig. 7: Composite nanoparticle distribution in the body and vital organs quantified using EPR spectroscopy.

Fig. 7:

A) After 14 days, 44.7% of composite nanoparticles remained in the 5-month rats, 45.1% remained in the 10-month rats, and 62.5% remained in the 15-month rats. Significantly more nanoparticles remained in the 15-month compared to the 5- (p = 0.0002) and 10-month (p = 0.0002) rats. Nanoparticle distribution in the whole body was further analyzed to determine nanoparticle accumulation in the B) heart, C) lungs, D) spleen, E) kidneys, and F) liver. No differences were found for particle distribution in vital organs as a function of age. Bar graphs represent mean + 95% confidence interval. (2-column fitting image)