FIGURE 4.

RSV changed the function of the gut microbiota in HFD-fed mice. (A) The linear discriminant analysis (LDA) effect size (LEfSe) showed the relevant KEGG pathways predicted by PICRUSt (LDA score > 3.0 and significance of P < 0.05 analyzed by the Wilcoxon signed-rank test). (B) Principle coordinate analysis (PCoA) showed the Bray–Curtis distance of the predicted KEGG pathways in the three groups. (C) Glucose and lipid metabolic pathways that were altered between groups. Data are shown as the mean ± SEM, the Kruskal–Wallis and Wilcoxon tests were performed in LEfSe, ANOSIM was used for similarities in PCoA. *p < 0.05; and ****p < 0.0001 vs NC group, ^#p < 0.05 vs HFD group.