Table 1A.

Determination of SRC frequency determined by limiting dilution assay in NSG mice.

Culture conditions	Cell transplanted		Number of mice with >1% human cell chimerism/total number of mice
Day 0 Uncultured		500	0/3
		2500	0/3
		10000	¾
	Number of CD34+ cells at starting	Number of CD34+ cells at transplanted
Vehicle control	500	1.9×104±1.8×103	0/4
	2500	8.9×104±9.1×103	¼
	10000	3.6×105±3.6×104	2/4
Eupalinilide E	500	1.5×104±2.8×103	1/3
	2500	7.7×104±1.4×104	0/4
	10000	3.1×105±5.6×104	¾
UM171	500	1.3×104±1.1×103	¼
	2500	6.3×104±5.4×103	2/4
	10000	2.5×105±2.2×104	3/3
Eupalinilide E +UM171	500	9.0×103±0.3×103	¾
	2500	4.5×104±1.7×103	4/4
	10000	1.8×105±6.9×103	4/4

^*Calculations (Table 1A) were from input (Day 0) CB CD34⁺ cells, and from output (Day 7) of cytokine stimulated cultures in presence of vehicle control, Eupalinilide E, UM171, and Eupalinilide E plus UM171.