. Author manuscript; available in PMC: 2021 Oct 1.

Published in final edited form as: Am J Surg Pathol. 2020 Oct;44(10):1406–1412. doi: 10.1097/PAS.0000000000001533

Table 4.

Clinical, pathologic and molecular features of tumors arising in ASH and NASH (Japan cohort).

	ASH	NASH
N	45	58
Age, y mean (SD)	66.6 (7.7)	70.2 (9.7)	p = 0.01
M:F ratio	45:0	45:13	p < 0.001
# tumors mean (SD)	1.2 (0.7)	1.3 (1.0)	p = 0.5
Tumor size, cm Mean (SD)	3.5 (2.1)	5.2 (3.3)	p = 0.001
Tumor differentiation (per tumor region)			p = 0.67
Well	4 (8.7%)	6 (9.1%)
Moderate	38 (83%)	57 (86%)
Poor	4 (8.7%)	3 (4.5%)
Microscopic vascular invasion	8 (17.8%)	5 (8.6%)	p = 0.14
Macroscopic vascular invasion	4 (8.9%)	0 (0%)	p = 0.03
AFP > 9	14 (31%)	21 (36%)	p = 0.68
Steatohepatitic HCC	16 (36%)	15 (26%)	p = 0.39
Molecular subtype (per tumor region)			p = 0.49
S1	15 (33%)	15 (23%)
S2	6 (13%)	11 (17%)
S3	25 (54%)	40 (60%)