Table 1.
GO Enrichment and KEGG Pathway Analysis of Differently Expressed RBPs
| GO Term | Name | P value | FDR | |
|---|---|---|---|---|
| Down-regulated RBPs | Cellular Component | U2-type spliceosomal complex | 2.07E-08 | 6.09E-06 |
| Spliceosomal snRNP complex | 4.95E-07 | 9.51E-05 | ||
| U2-type prespliceosome | 5.67E-07 | 9.51E-05 | ||
| Prespliceosome | 5.67E-07 | 9.51E-05 | ||
| U1 snRNP | 3.68E-09 | 1.44E-06 | ||
| Molecular Function | RNA binding | 0 | 0 | |
| mRNA binding | 5.81E-9 | 5.45E-6 | ||
| snRNA binding | 4.60E-5 | 2.88E-2 | ||
| Biological Process | Positive regulation of mRNA processing | 2.27E-05 | 1.15E-02 | |
| mRNA splice site selection | 2.06E-05 | 1.10E-02 | ||
| Positive regulation of RNA splicing | 4.19E-07 | 4.23E-04 | ||
| Positive regulation of mRNA splicing, via spliceosome | 7.14E-06 | 4.06E-03 | ||
| Regulation of chaperone-mediated autophagy | 8.14E-05 | 3.89E-02 | ||
| KEGG pathway | Spliceosome | 3.19E-5 | 1.04E-2 | |
| Up-regulated RBPs | Cellular Component | U1 snRNP | 2.17E-12 | 1.06E-10 |
| U4 snRNP | 2.81E-9 | 8.48E-8 | ||
| U12-type spliceosomal complex | 1.33E-15 | 1.04E-13 | ||
| Box H/ACA snoRNP complex | 3.73E-5 | 6.09E-4 | ||
| Histone pre-mRNA 3ʹend processing complex | 5.43E-9 | 1.59E-7 | ||
| Molecular Function | RNA 7-methylguanosine cap binding | 1.50E-5 | 6.40E-4 | |
| Exoribonuclease activity, producing 5ʹ-phosphomonoesters | 6.66E-16 | 1.25E-13 | ||
| Transforming growth factor beta receptor, pathway-specific cytoplasmic mediator | 6.62E-5 | 2.44E-3 | ||
| Box H/ACA snoRNA binding | 6.62E-5 | 2.44E-3 | ||
| snRNP binding | 4.30E-6 | 2.18E-4 | ||
| Biological Process | Ribosomal subunit export from nucleus | 1.59E-07 | 1.24E-05 | |
| Termination of RNA polymerase II transcription | 1.38E-14 | 1.90E-12 | ||
| Positive regulation of cytoplasmic mRNA processing body assembly | 1.18E-04 | 4.84E-03 | ||
| Regulation of ribonuclease activity | 2.40E-07 | 1.80E-05 | ||
| mRNA cleavage involved in gene silencing | 5.97E-05 | 2.66E-03 | ||
| KEGG pathway | Aminoacyl-tRNA biosynthesis | 3.13E-8 | 1.70E-6 | |
| Ribosome biogenesis in eukaryotes | 0 | 0 | ||
| RNA transport | 2.22E-16 | 2.41E-14 | ||
| mRNA surveillance pathway | 5.33E-15 | 4.34E-13 | ||
| RNA degradation | 6.75E-14 | 4.40E-12 | ||
| Spliceosome | 0 | 0 |