FIGURE 1.

High fat feeding leads to whole body diurnal metabolic inflexibility. A, Body weight was assessed once every 2‐wk, in mice that were fed either a control or high fat diet in an ad libitum fashion for 20‐wk (n = 20‐21). B, After 20‐wk of control or high fat diet feeding, body weight (i), fat mass (ii) and lean mass (iii) were assessed (n = 5). C, After 18‐wk of control or high fat diet feeding, 24‐h patterns in caloric intake (i), physical activity (ii), energy expenditure (iii), and respiratory exchange ratio (RER; iv) were assessed (n = 25‐27). Data are reported as mean ± SEM. Main effects for either time, diet, and/or interaction are reported at the top of the figure panels. *P < .05 for control (circle) vs high fat (square)