TABLE 6.
Functional parameters for ex vivo perfused hearts isolated from time‐of‐day‐restricted control and high fat diet fed mice
| Control diet time‐restricted | High fat diet time‐restricted | |||
|---|---|---|---|---|
| ZT5 | ZT17 | ZT5 | ZT17 | |
| Cardiac power (CP; mW) | 1.32 ± 0.08 | 1.36 ± 0.08 | 1.24 ± 0.06 | 1.19 ± 0.07 |
| Heart rate (BPM) | 307 ± 13 | 314 ± 10 | 293 ± 15 | 297 ± 17 |
| Developed Pressure (mm Hg) | 26.7 ± 2.2 | 31.6 ± 1.9 | 29.8 ± 2.3 | 30.7 ± 2.0 |
| Rate pressure product (BPM × mm Hg) | 8107 ± 655 | 9816 ± 534 | 8728 ± 770 | 8940 ± 569 |
| Oxygen consumption (MVO2; umoles/min/g dry wt) | 8.02 ± 1.22 | 9.45 ± 0.83 | 7.86 ± 0.92 | 7.60 ± 0.88 |
| Cardiac efficiency (CP/MVO2) | 0.19 ± 0.02 | 0.15 ± 0.01 | 0.17 ± 0.02 | 0.17 ± 0.02 |
Data are reported as mean ± SEM for 10‐13 mice per experimental group.