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. 2021 Mar 9;17(3):e1009410. doi: 10.1371/journal.pgen.1009410

Fig 8. AKT-dependent TRF1 phosphorylation is essential for tumor growth.

Fig 8

A. Tumor volume follow-up in mice injected with wild type and mutant TRF1T358A/T358A and TRF1T273A/T273A HEK293T cells. B. Representative image (left) and weight (right) of wild-type and TRF1T358A/T358A and TRF1T273A/T273A mutant xenografts. C-H. Representative images (C) and quantification of Ki-67 (D), γH2AX (E), Caspase-3 (F), TRF1 (G) and nuclear telomere length (H) of wild-type and TRF1T358A/T358A and TRF1T273A/T273A mutant xenografts. Scale bars are indicated. Bars and error bars represent mean values ± SE. n represents number of tumors. Student’s t-test was used for the statistical analysis; *p < 0.05, **p < 0.01, ***p < 0.001 ns, no significant.