Fig 3. Network of proteins affected by metformin and insulin supplementation.

Proteins that displayed a |log₂FC| ≥ 0.5 and/or an adjusted p value ≤ 0.05 (total number: 80) were subjected to STRING analysis and protein clusters for biological processes (A, 53 proteins) or molecular functions (B, 31 proteins) were identified with the GO database. (A) Biological processes were divided into subsets related to cell population proliferation (red, 12 proteins), cell adhesion (blue, 20 proteins), cell migration (green, 23 proteins), and immune response (yellow, 29 proteins). A total of 27 proteins could not be assigned to any of the four biological processes (not shown). (B) Identified molecular functions included growth factor (red, 12 proteins), cytokine (blue, 14 proteins), chemokine (green, 3 proteins), and signal receptor activity (yellow, 13 proteins). A total of 50 proteins could not be assigned to any of the four molecular functions (not shown).