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. 2021 Mar 9;16(3):e0241654. doi: 10.1371/journal.pone.0241654

Fig 1. Scheme of a negative feedback with integral control regulating variable A.

Fig 1

The difference between the set-point Aset and the actual value of A (the error ϵ) is integrated over time and fed back into the process which generates A. This procedure ensures that A will precisely reach Aset for step-wise perturbations. Colors correspond to molecular reactions shown later.