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. Author manuscript; available in PMC: 2022 Jan 26.
Published in final edited form as: ACS Nano. 2020 Dec 22;15(1):1608–1626. doi: 10.1021/acsnano.0c09206

Table 1.

Comparison of different NP formulations for hydrodynamic size, PDI, zeta potential, loading capacity, and cargo encapsulation efficiency.

Nanoparticle Hydrodynamic size
(nm)		 PDI Zeta potential
(mV)		 Loading capacity
(μg/mg NPs)		 Encapsulation
efficiency
(%)		 OVA content
(μg/mg NPs)
Empty NP 231.2 ± 2.17 0.096 −42.55 ± 2.99 NA NA NA
NPOVA 246.5 ± 3.01 0.105 −44.37 ± 2.81 NA NA 51.61 ± 2.32
NPApoBP 250.9 ± 3.81 0.112 −11.44 ± 4.02 11.65 ± 0.75
(ApoBP ligand)		 5.1
(mol% of PLGA)		 NA
NPOVA/ApoBP 270.8 ± 4.96 0.113 −4.56 ± 2.25 12.96 ± 0.77
(ApoBP ligand)		 5.3
(mol% of PLGA)		 50.12 ± 2.18
NPCurcumin 251.2 ± 3.27 0.108 −35.77 ± 3.52 66.12 ± 3.70 38.94 ± 2.14 NA
NPOVA-Curcumin 255.7 ± 4.44 0.129 −38.42 ± 2.95 64.52 ± 2.69 37.06 ± 3.62 50.66 ± 2.68
NPRapa 246.3 ± 5.47 0.120 −36.28 ± 3.41 23.44 ± 3.56 33.66 ± 5.24 NA
NPOVA-Rapa 252.5 ± 3.88 0.139 −39.38 ± 2.99 22.31 ± 6.58 31.77 ± 3.94 46.88 ± 2.76