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. Author manuscript; available in PMC: 2021 Oct 1.
Published in final edited form as: Curr Opin Physiol. 2020 Sep 11;17:269–277. doi: 10.1016/j.cophys.2020.08.020

Fig. 3.

Fig. 3.

(Top) Working model proposed by Yang et al. Ca2+ activates CaSR first, then activation is enhanced by amino acid (AA)/TNCA. (Bottom) Working model proposed by Geng et al. L-amino acid activates the receptor, and Ca2+ stabilizes the active state to further activate the receptor.