Table 2. Effect of different doses of berberine on urinary uric acid level (mg/dl) of hyperuricemic rats (n = 6) on day 0, 1, 3 and 7.

Urinary Uric Acid (mg/dl)
	Groups	Day 0 Mean ± SD	Day 1 Mean ± SD	Day 3 Mean ± SD	Day 7 Mean ± SD	Repeated measure ANOVA p-value
	Normal control (A)	7.4 ± 2.3	7.3 ± 2.3	7.0 ± 1.9	7.2 ± 1.9	0.403
	Disease control (B)	7.6 ± 2.2	10.9 ± 3.2	12.6 ± 3.0	14.6 ± 2.9	0.067
	Standard drug Allopurinol (C)	9.4 ± 1.2	11.7 ± 3.5	9.6 ± 3.5	7.8 ± 3.3	0.182
	Low dose berberine (D)	8.6 ± 3.8	6.9 ± 4.5	20.4 ± 12.7	48.5 ± 10.2	0.028
	Medium dose berberine (E)	10.1 ± 5.5	6.5 ± 4.7	12.3 ± 6.2	24.7 ± 10.9	0.025
	High dose berberine (F)	7.2 ± 2.9	4.8 ± 1.9	6.8 ± 2.1	17.1 ± 7.3	0.052
	p-value (ANOVA)	0.575	0.01	0.007	<0.001