Table 1. Genes dysregulated by HAND2 knockdown are enriched in pathways relevant to endometrial stromal cells and pregnancy in general.

Enriched pathway	Roles in ESFs and pregnancy	References
Wnt Signaling	Decidualization	Peng et al., 2008; Hayashi et al., 2009; Sonderegger et al., 2010; Franco et al., 2011; Wang et al., 2013
BMP Signaling	Decidualization	Ying and Zhao, 2000; Lee et al., 2007; Li et al., 2007; Wetendorf and DeMayo, 2012
ErbB Signaling	Decidualization	Lim et al., 1997; Klonisch et al., 2001; Large et al., 2014
TGF-beta Receptor Signaling	Decidualization	Jones et al., 2006; Li, 2014; Ni and Li, 2017
BMP2-WNT4-FOXO1 Pathway in Human Primary Endometrial Stromal Cell Differentiation	Decidualization	Gellersen and Brosens, 2003; Buzzio et al., 2006; Lee et al., 2007; Li et al., 2007; Brayer et al., 2011; Lynch et al., 2009; Kajihara et al., 2013
AGE/RAGE Pathway	Placental bed development disorders Preeclampsia Induction of pro-inflammatory factors via nuclear factor-κB (NFκB)	Chekir et al., 2006; Lappas et al., 2007; Oliver et al., 2011; Guedes-Martins et al., 2013
Aryl Hydrocarbon Receptor Pathway	Mediation of maternal immunotolerance to fetal allograft	Munn et al., 1998; Abbott et al., 1999; Funeshima et al., 2005; Hao et al., 2013
Circadian Rhythm Related Genes	Implantation and parturition	Roizen et al., 2007; Olcese, 2012; Olcese et al., 2013; Greenhill, 2014; Menon et al., 2016
RAC1/PAK1/p38/MMP2 Pathway	Decidual inflammation, senescence and parturition	Menon et al., 2016