Fig. 1. Docking for PLX4032 in wild type BRAF and V600E mutant binding patterns of PLX4032 on BRAF. Molecular docking of PLX4032 with BRAF wild type and V600E. (A) The first panel illustrates PLX4032 docked into the hydrophobic core of wild type BRAF showing hydrogen, hydrophobic, and cation interactions. (B) The second panel indicates the best-docked confirmation of PLX4032 into BRAFV600E along with binding interactions representation.
