Table 2.
Pathway enrichment analysis of differentially expressed genes among the FAM83 family.
| KEGG pathway | Fold enrichment | p value | Related genes |
|---|---|---|---|
| FAM83A | |||
| ECM-receptor interaction | 23.28297 | 3.10E-05 | LAMB3, ITGB6, ITGB4, LAMC2, ITGA3 |
| Focal adhesion | 11.67623 | 5.80E-05 | LAMB3, ITGB6, ITGB4, LAMC2, ITGA3, FLNB |
| Pathways in cancer | 4.770169 | 0.037837 | LAMB3, SLC2A1, LAMC2, ITGA3 |
| FAM83D | |||
| Cell cycle | 26.15143 | 1.24E-10 | CCNB1, CDK1, CCNB2, PLK1, BUB1, BUB1B, TTK, CDC25C, CCNA2 |
| Oocyte meiosis | 23.11364 | 1.36E-07 | CCNB1, CDK1, CCNB2, PLK1, BUB1, AURKA, CDC25C |
| p53 signaling pathway | 21.36555 | 5.94E-04 | CCNB1, CDK1, CCNB2, RRM2 |
| FAM83E | |||
| Axon guidance | 4.125203 | 0.001289 | SEMA4G, EFNA1, EFNA2, CFL2, EFNB1, MAPK3, PPP3CB, EFNA4, CXCL12 |
| Tight junction | 3.971277 | 0.001647 | CLDN7, MPDZ, CGN, CRB3, MYH14, AMOTL1, TJP3, SRC, AKT3 |
| Glycosphingolipid biosynthesis | 9.460465 | 0.00795 | FUT6, FUT3, B3GNT3, FUT2 |
| ErbB signaling pathway | 4.077787 | 0.014669 | CBLC, ERBB2, MAPK3, MAPK10, SRC, AKT3 |
| Fc gamma R-mediated phagocytosis | 3.734394 | 0.020746 | MARCKSL1, CFL2, MAPK3, VASP, AKT3, DNM2 |
| VEGF signaling pathway | 3.94186 | 0.036037 | PLA2G10, MAPK3, PPP3CB, SRC, AKT3 |
| Adherens junction | 3.839474 | 0.039139 | FGFR1, ERBB2, MAPK3, TCF7L2, SRC |
| FAM83H | |||
| Axon guidance | 3.742273 | 3.61E-05 | NGEF, EFNB1, EPHB4, CXCL12, EPHA2, SLIT3, SEMA5A, SEMA3G, FYN, CFL2, RAC1, PPP3CB, SEMA4B, EFNA4, RHOD |
| Cell adhesion molecules (CAMs) | 2.925777 | 0.002361 | F11R, CLDN7, SDC1, CLDN4, CD34, NRXN3, PECAM1, NLGN4X, JAM2, SDC4, NEGR1, CDH5 |
| Calcium signaling pathway | 2.377194 | 0.007799 | SLC8A3, EDNRB, PLCB3, SLC8A1, PTGER3, ADORA2A, TACR1, ERBB2, PDE1A, PPP3CB, PLCD3, PTGFR, ITPR1 |
| Tight junction | 2.641933 | 0.008055 | F11R, EPB41L3, CLDN7, CTTN, CLDN4, MPDZ, CGN, MYH14, JAM2, TJP3, MYH10 |
| Leukocyte transendothelial migration | 2.727419 | 0.010253 | F11R, CLDN7, CLDN4, PECAM1, RAC1, RAPGEF4, JAM2, CXCL12, CDH5, VASP |
| Pathways in cancer | 1.66805 | 0.04474 | CKS1B, FGFR1, ERBB2, STAT5B, SMAD4, ITGA3, BCL2L1, MAPK10, FZD4, JUP, CBLC, LAMB3, BCL2, RAC1, PIAS2, TRAF4, GSTP1 |