Table.
Patient demographic and clinical characteristics
| All patients (n=1080) |
Patients admitted to ICU |
Patients never admitted to ICU (n=432) | ||
|---|---|---|---|---|
| Admitted to ICU on same day as hospitalisation (n=431) | Admitted to ICU ≥1 day after hospitalisation (n=217) | |||
| Sex (n=1078) | ||||
| Female | 476 (44%) | 194 (45%) | 81 (37%) | 201 (47%) |
| Male | 602 (56%) | 236 (55%) | 136 (63%) | 230 (53%) |
| Age, years (n=1078) | ||||
| 0–5 | 373 (35%) | 123 (29%) | 52 (24%) | 198 (46%) |
| 6–12 | 456 (42%) | 185 (43%) | 113 (52%) | 158 (37%) |
| 13–20 | 249 (23%) | 123 (29%) | 52 (24%) | 74 (17%) |
| Race or ethnicity (n=945) | ||||
| Non-Hispanic White | 133 (14%) | 49 (13%) | 26 (14%) | 58 (15%) |
| Non-Hispanic Black | 339 (36%) | 154 (40%) | 67 (37%) | 118 (31%) |
| Hispanic | 385 (41%) | 148 (39%) | 73 (40%) | 164 (43%) |
| Other race or ethnicity | 88 (9%) | 30 (8%) | 15 (8%) | 43 (11%) |
| Comorbidities | ||||
| Obesity | 286 (26%) | 119 (28%) | 70 (32%) | 97 (22%) |
| Date of MIS-C onset | ||||
| Onset before June 1, 2020 | 439 (41%) | 179 (42%) | 106 (49%) | 154 (36%) |
| Clinical signs and symptoms | ||||
| Cough | 322 (30%) | 134 (31%) | 58 (27%) | 130 (30%) |
| Shortness of breath | 287 (27%) | 146 (34%) | 67 (31%) | 74 (17%) |
| Abdominal pain | 693 (64%) | 285 (66%) | 162 (75%) | 246 (57%) |
| Vomiting | 684 (63%) | 284 (66%) | 139 (64%) | 261 (60%) |
| Diarrhoea | 573 (53%) | 241 (56%) | 108 (50%) | 224 (52%) |
| Rash | 584 (54%) | 229 (53%) | 117 (54%) | 238 (55%) |
| Mucocutaneous lesions | 313 (29%) | 116 (27%) | 61 (28%) | 136 (31%) |
| Conjunctival injection | 534 (49%) | 225 (52%) | 111 (51%) | 198 (46%) |
| Laboratory values | ||||
| Fibrinogen, mg/dL (n=721) | 544 (438–662) | 577 (466–695) | 547 (434–660) | 510 (419–631) |
| D-dimer, mg/L (n=747) | 2·4 (1·2–4·4) | 2·9 (1·6–5·5) | 3 (1·5–5) | 1·5 (0·8–3·3) |
| Troponin, ng/mL (n=793) | 0·05 (0·01–0·27) | 0·11 (0·03–0·52) | 0·09 (0·02–0·34) | 0·01 (0·01–0·08) |
| BNP, pg/mL (n=381) | 566 (146–1364) | 907 (368–1933) | 795 (345–1677) | 195 (48–694) |
| proBNP, ng/L (n=371) | 2054 (310–7778) | 4796 (1164–16 324) | 3341 (439–7320) | 558 (212–2605) |
| C-reactive protein, mg/dL (n=870) | 18 (10–26) | 22 (15–29) | 21 (14–28) | 13 (6–21) |
| Ferritin, ng/mL (n=790) | 463 (225–911) | 626 (350–1171) | 628 (333–1146) | 289 (156–529) |
| Interleukin-6, pg/mL (n=221) | 67 (17–208) | 81 (23–262) | 101 (26–322) | 43 (9–128) |
| Platelets, ×103 cells per μL (n=622) | 136 (94–211) | 121 (82–167) | 120 (83–184) | 172 (112–268) |
| Lymphocytes, cells per μL (n=501) | 950 (504–1945) | 858 (400–1600) | 705 (428–1308) | 1300 (790–2715) |
| Outcomes | ||||
| Admitted to ICU | 648 (60%) | 431 (100%) | 217 (100%) | 0 (0%) |
| Decreased cardiac function | 303 (28%) | 177 (41%) | 84 (39%) | 42 (10%) |
| Shock | 392 (36%) | 271 (63%) | 100 (46%) | 21 (5%) |
| Myocarditis | 192 (18%) | 108 (25%) | 53 (24%) | 31 (7%) |
| Coronary artery abnormality | 185 (17%) | 81 (19%) | 38 (18%) | 66 (15%) |
| Death | 18 (2%) | 10 (2%) | 4 (2%) | 4 (1%) |
Data are n (%) or median (IQR). Denominators for sex, age, race, and laboratory values represent the number with reported values; all other percentages are based on all 1080 patients. BNP=brain natriuretic peptide. ICU=intensive care unit. MIS-C=multisystem inflammatory syndrome in children. proBNP=N-terminal pro B-type BNP.