Table 1.
Changes in ACE2 expression levels induced by renin-angiotensin system inhibitors in animal models of human diseases
| The number of experiments | Under treatment | |||
|---|---|---|---|---|
| Overexpression | No/marginal change | Repression | Sum | |
| Baseline | ||||
| Overexpression | 12 | 5 | 1 | 18 |
| No/marginal change | 7 | 58 | 7 | 72 |
| Repression | 0 | 36 | 4 | 40 |
| Sum | 19 | 99 | 12 | 130 |
Overexpression was defined when ACE2 expression was greater than twice as much as the control group. Repression was defined when ACE2 expression was less than half of the control group. No/marginal change was defined when ACE2 expression remained within 1/2 to 2 times of the control group
ACE2 angiotensin-converting enzyme 2